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# ESM

## Overview
This page provides code and pre-trained weights for Transformer protein language models from Meta AI's Fundamental 
AI Research Team, providing the state-of-the-art ESMFold and ESM-2, and the previously released ESM-1b and ESM-1v.
Transformer protein language models were introduced in the paper [Biological structure and function emerge from scaling
unsupervised learning to 250 million protein sequences](https://www.pnas.org/content/118/15/e2016239118) by 
Alexander Rives, Joshua Meier, Tom Sercu, Siddharth Goyal, Zeming Lin, Jason Liu, Demi Guo, Myle Ott, 
C. Lawrence Zitnick, Jerry Ma, and Rob Fergus.
The first version of this paper was [preprinted in 2019](https://www.biorxiv.org/content/10.1101/622803v1?versioned=true).

ESM-2 outperforms all tested single-sequence protein language models across a range of structure prediction tasks,
and enables atomic resolution structure prediction.
It was released with the paper [Language models of protein sequences at the scale of evolution enable accurate
structure prediction](https://doi.org/10.1101/2022.07.20.500902) by Zeming Lin, Halil Akin, Roshan Rao, Brian Hie,
Zhongkai Zhu, Wenting Lu, Allan dos Santos Costa, Maryam Fazel-Zarandi, Tom Sercu, Sal Candido and Alexander Rives.

Also introduced in this paper was ESMFold. It uses an ESM-2 stem with a head that can predict folded protein
structures with state-of-the-art accuracy. Unlike [AlphaFold2](https://www.nature.com/articles/s41586-021-03819-2),
it relies on the token embeddings from the large pre-trained protein language model stem and does not perform a multiple
sequence alignment (MSA) step at inference time, which means that ESMFold checkpoints are fully "standalone" -
they do not require a database of known protein sequences and structures with associated external query tools
to make predictions, and are much faster as a result.


The abstract from 
"Biological structure and function emerge from scaling unsupervised learning to 250 
million protein sequences" is


*In the field of artificial intelligence, a combination of scale in data and model capacity enabled by unsupervised
learning has led to major advances in representation learning and statistical generation. In the life sciences, the
anticipated growth of sequencing promises unprecedented data on natural sequence diversity. Protein language modeling
at the scale of evolution is a logical step toward predictive and generative artificial intelligence for biology. To
this end, we use unsupervised learning to train a deep contextual language model on 86 billion amino acids across 250
million protein sequences spanning evolutionary diversity. The resulting model contains information about biological
properties in its representations. The representations are learned from sequence data alone. The learned representation
space has a multiscale organization reflecting structure from the level of biochemical properties of amino acids to
remote homology of proteins. Information about secondary and tertiary structure is encoded in the representations and
can be identified by linear projections. Representation learning produces features that generalize across a range of
applications, enabling state-of-the-art supervised prediction of mutational effect and secondary structure and
improving state-of-the-art features for long-range contact prediction.*


The abstract from
"Language models of protein sequences at the scale of evolution enable accurate structure prediction" is

*Large language models have recently been shown to develop emergent capabilities with scale, going beyond
simple pattern matching to perform higher level reasoning and generate lifelike images and text. While
language models trained on protein sequences have been studied at a smaller scale, little is known about
what they learn about biology as they are scaled up. In this work we train models up to 15 billion parameters,
the largest language models of proteins to be evaluated to date. We find that as models are scaled they learn
information enabling the prediction of the three-dimensional structure of a protein at the resolution of
individual atoms. We present ESMFold for high accuracy end-to-end atomic level structure prediction directly
from the individual sequence of a protein. ESMFold has similar accuracy to AlphaFold2 and RoseTTAFold for
sequences with low perplexity that are well understood by the language model. ESMFold inference is an
order of magnitude faster than AlphaFold2, enabling exploration of the structural space of metagenomic
proteins in practical timescales.*


Tips:

- ESM models are trained with a masked language modeling (MLM) objective.

The original code can be found [here](https://github.com/facebookresearch/esm) and was
was developed by the Fundamental AI Research team at Meta AI.
ESM-1b, ESM-1v and ESM-2 were contributed to huggingface by [jasonliu](https://huggingface.co/jasonliu)
and [Matt](https://huggingface.co/Rocketknight1).

ESMFold was contributed to huggingface by [Matt](https://huggingface.co/Rocketknight1) and
[Sylvain](https://huggingface.co/sgugger), with a big thank you to Nikita Smetanin, Roshan Rao and Tom Sercu for their
help throughout the process!

The HuggingFace port of ESMFold uses portions of the [openfold](https://github.com/aqlaboratory/openfold) library.
The `openfold` library is licensed under the Apache License 2.0.

## EsmConfig

[[autodoc]] EsmConfig
    - all

## EsmTokenizer

[[autodoc]] EsmTokenizer
    - build_inputs_with_special_tokens
    - get_special_tokens_mask
    - create_token_type_ids_from_sequences
    - save_vocabulary


## EsmModel

[[autodoc]] EsmModel
    - forward

## EsmForMaskedLM

[[autodoc]] EsmForMaskedLM
    - forward

## EsmForSequenceClassification

[[autodoc]] EsmForSequenceClassification
    - forward

## EsmForTokenClassification

[[autodoc]] EsmForTokenClassification
    - forward

## EsmForProteinFolding

[[autodoc]] EsmForProteinFolding
    - forward

## TFEsmModel

[[autodoc]] TFEsmModel
    - call

## TFEsmForMaskedLM

[[autodoc]] TFEsmForMaskedLM
    - call

## TFEsmForSequenceClassification

[[autodoc]] TFEsmForSequenceClassification
    - call

## TFEsmForTokenClassification

[[autodoc]] TFEsmForTokenClassification
    - call
